# Intronator
A Python package for intron analysis with splice site prediction capabilities.
## Features
- SpliceAI integration for splice site prediction
- Pangolin model support for enhanced predictions
- seqmat compatibility for sequence analysis
- Python 3.10+ support
## Installation
### Basic Installation
```bash
pip install intronator
```
### External Dependencies
The package requires SpliceAI and Pangolin models which must be installed separately:
#### SpliceAI
```bash
pip install spliceai
```
#### Pangolin
```bash
pip install git+https://github.com/tkzeng/Pangolin.git
```
#### Complete Installation (with external dependencies)
```bash
pip install intronator[external]
```
## Quick Start
```python
import intronator
# Check package status
print(intronator.hello_intronator())
print(intronator.check_seqmat_compatibility())
print(intronator.get_model_status())
```
## Requirements
- Python >= 3.10
- seqmat
- torch >= 1.10.0
- tensorflow >= 2.8.0
- SpliceAI (install separately)
- Pangolin (install separately)
## Notes
- SpliceAI and Pangolin models will be automatically loaded when the package is imported
- Model loading may take some time on first import
- GPU acceleration is automatically detected and used when available
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